超音波検査技術

ISSN: 1881-4506
一般社団法人日本超音波検査学会
〒162-0801 東京都新宿区山吹町358-5
Japanese Journal of Medical Ultrasound Technology 47(3): 252-259 (2022)
doi:10.11272/jss.349

症例報告Case Report

下肢静脈超音波検査時に骨盤腔内の巨大腫瘤性病変の質的診断が有用であったTrousseau症候群の1例A Case of Trousseau’s Syndrome Evaluated with Lower Extremity Venous Ultrasonography Leading to a Qualitative Diagnosis of a Large Pelvic Mass

1滋賀県立総合病院臨床検査部Clinical Laboratory, Shiga General Hospital

2滋賀県立総合病院循環器内科Department of Cardiology, Shiga General Hospital

3滋賀県立総合病院婦人科Department of Gynecology, Shiga General Hospital

受付日:2021年3月16日Received: March 16, 2021
受理日:2022年1月31日Accepted: January 31, 2022
発行日:2022年6月1日Published: June 1, 2022
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症例は60代女性.誘因なく右大腿内側に疼痛と腫脹が出現したため近医を受診.DダイマーとCRP上昇を認めたため,当院循環器内科紹介となった.深部静脈血栓症検索目的に下肢静脈超音波検査が行われ,右膝窩静脈から後脛骨静脈,腓骨静脈,ひらめ静脈に血栓を認めた.右大伏在静脈は総大腿静脈合流部まで血栓を認めた.さらなる広範囲の血栓を疑って腹部領域の検索を追加したところ,骨盤腔内に巨大腫瘤を認めた.腫瘤は充実性優位の混合性パターンであり,卵巣癌を疑った.循環器内科で深部静脈血栓症に対してリバーロキサバンによる抗凝固療法が開始され,婦人科での精査中に,多発脳梗塞を発症し,ヘパリン点滴による脳梗塞の治療を並行して行った.CTおよびMRI骨盤画像検査で卵巣癌と診断し,卵巣癌切除術が施行され,病理組織検査で卵巣癌IC3期,明細胞癌と診断された.多発脳梗塞および先行した深部静脈血栓症はTrousseau症候群によるものと診断された.今回我々は横断領域における走査が有用であったTrousseau症候群を伴った早期卵巣癌の1例を経験したので報告する.

A woman in her 60s presented to her local physician with a spontaneous onset of pain and swelling on the medial side of her right thigh. D-dimer and C-reactive protein (CRP) levels were tested and found to be increased, and she was then referred to our hospital’s cardiology department. A lower extremity venous ultrasonography was performed and thrombi were observed in the popliteal, peroneal, posterior tibial, and soleal veins in the right leg. The right great saphenous vein was also found to have a thrombus up to the confluence of the femoral vein. Suspecting more extensive thrombi, an examination of the abdominal region was performed, and a large tumor was discovered in the pelvis. The tumor had a mixed pattern on ultrasound, with a predominantly solid body and was suspected to be malignant and of ovarian origin. She was started on anticoagulation with rivaroxaban in the Department of Cardiology, after which she was referred to a gynecologist. During a thorough examination in the Department of Gynecology, multiple cerebral infarctions occurred and were treated immediately with intravenous heparin. Ovarian cancer stage I was suspected on Computed Tomography (CT) and Magnetic Resonance Imaging (MRI) of the pelvic region. She was taken to surgery with complete resection of the tumor and surgical staging and a final diagnosis of ovarian clear cell carcinoma stage IC3. Multiple cerebral infarctions and prior deep vein thrombosis were also diagnosed and were attributed to Trousseau’s syndrome. While it is well-known that malignancies increase thrombogenesis, it is still rare for a malignancy to be detected at the onset of deep vein thrombosis. This case report is of a Stage IC3 ovarian cancer detected during evaluation of suspected Trousseau’s syndrome, during ultrasound evaluation of the lower extremity and further defined as potentially malignant pre-operatively during cross sectional scanning.

Key words: trousseau’s syndrome; deep vein thrombosis; ovarian cancer; lower extremity venous ultrasonography; cross sectional scanning

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